GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11072804 | 1 | rs11072804 | chr15:79078486 | CTSH | chr15:79214092-79237420:- | 0.17 | 4.84 | 1.48E-6 | Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs11072805 | 1 | rs11072805 | chr15:79078518 | CTSH | chr15:79214092-79237420:- | 0.17 | 4.82 | 1.61E-6 | Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs2840044 | 1 | rs11080357 | chr17:33898933 | SLFN12L | chr17:33801926-33864880:- | 0.08 | 4.78 | 2.0E-6 | Response to radiotherapy in cancer (late toxicity) |
| BRCA | cis | rs11083475 | 1 | rs11083475 | chr19:39188112 | LGALS7 | chr19:39261608-39264157:- | -0.19 | -6.06 | 1.92E-9 | Heart rate |
| BRCA | cis | rs4889609 | 1 | rs1108431 | chr16:31054607 | HSD3B7 | chr16:30996519-31000473:+ | 0.2 | 6.09 | 1.59E-9 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs1108431 | chr16:31054607 | MYST1 | chr16:31128985-31142713:+ | 0.18 | 6.67 | 4.12E-11 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs1108431 | chr16:31054607 | PRSS53 | chr16:31094747-31106276:- | -0.09 | -3.42 | 0.000653 | Response to metformin (IC50) |
| BRCA | cis | rs4889609 | 1 | rs1108431 | chr16:31054607 | ZNF689 | chr16:30614701-30621682:- | 0.13 | 3.93 | 8.95E-5 | Response to metformin (IC50) |
| BRCA | cis | rs11084786 | 1 | rs11084785 | chr19:35282054 | ZNF181 | chr19:35225151-35233774:+ | -0.19 | -6.49 | 1.32E-10 | Urate levels (BMI interaction) |
| BRCA | cis | rs11084786 | 1 | rs11084786 | chr19:35282181 | ZNF181 | chr19:35225151-35233774:+ | -0.2 | -6.57 | 7.86E-11 | Urate levels (BMI interaction) |
| BRCA | cis | rs12608504 | 1 | rs11086102 | chr19:18398628 | JUND | chr19:18390563-18392432:- | -0.12 | -3.73 | 0.000202 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs12608504 | 1 | rs11086102 | chr19:18398628 | KIAA1683 | chr19:18367906-18385319:- | -0.17 | -5.04 | 5.52E-7 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs7267979 | 1 | rs11087520 | chr20:25436827 | FAM182A | chr20:26035250-26067552:+ | -0.23 | -6.01 | 2.49E-9 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs11087520 | chr20:25436827 | FAM182B | chr20:25744102-25848786:- | 0.23 | 6.08 | 1.65E-9 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs11087520 | chr20:25436827 | PYGB | chr20:25228706-25278647:+ | -0.13 | -3.5 | 0.000481 | Liver enzyme levels (alkaline phosphatase) |